AK-Spore

Generic Name: gramicidin, neomycin, and polymyxin B ophthalmic (gram i SYE din, NEE oh MYE sin, POL ee MIX in B off THAL mik)

Brand Names: Neosporin Ophthalmic, Ocu-Spore-G

What is AK-Spore (gramicidin, neomycin, and polymyxin B ophthalmic)?

Gramicidin, neomycin, and polymyxin B are all antibiotics. They are used to treat bacterial infections.

The ophthalmic form of gramicidin, neomycin, and polymyxin B is used to treat bacterial infections of the eyes.

Gramicidin, neomycin, and polymyxin B ophthalmic may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about AK-Spore (gramicidin, neomycin, and polymyxin B ophthalmic)?

Contact your doctor if your symptoms begin to get worse or if you do not see any improvement in your condition after a few days.

Do not touch the dropper to any surface, including your eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye.

Apply light pressure to the inside corner of your eye (near your nose) after each drop to prevent the liquid from draining down your tear duct.

Who should not use AK-Spore (gramicidin, neomycin, and polymyxin B ophthalmic)?

Do not use gramicidin, neomycin, and polymyxin B ophthalmic if you have a viral or fungal infection in your eye. It is used to treat infections caused by bacteria only. It is not known whether gramicidin, neomycin, and polymyxin B ophthalmic will harm an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant. It is not known whether gramicidin, neomycin, and polymyxin B ophthalmic passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use AK-Spore (gramicidin, neomycin, and polymyxin B ophthalmic)?

Use gramicidin, neomycin, and polymyxin B eyedrops exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using your eyedrops.

To apply the eyedrops:

• 
  

  Tilt your head back slightly and pull down on your lower eyelid. Position the dropper above your eye. Look up and away from the dropper. Squeeze out a drop and close your eye. Apply gentle pressure to the inside corner of your eye (near your nose) for about 1 minute to prevent the liquid from draining down your tear duct. If you are using more than one drop in the same eye or drops in both eyes, repeat the process with about 5 minutes between drops.

  
  

Do not touch the dropper to any surface, including your eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye. Do not use any eyedrop that is discolored or has particles in it. Store gramicidin, neomycin, and polymyxin B ophthalmic at room temperature away from moisture and heat. Keep the bottle properly capped.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

An overdose of this medication is unlikely to occur. If you do suspect an overdose, wash the eye with water and call an emergency room or poison control center near you. If the drops have been ingested, drink plenty of fluid and call an emergency center for advice.

What should I avoid while using AK-Spore (gramicidin, neomycin, and polymyxin B ophthalmic)?

Do not touch the dropper to any surface, including your eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye. Use caution when driving, operating machinery, or performing other hazardous activities. Gramicidin, neomycin, and polymyxin B ophthalmic may cause blurred vision. If you experience blurred vision, avoid these activities.

Use caution with contact lenses. Wear them only if your doctor approves. After applying this medication, wait at least 15 minutes before inserting contact lenses.

Avoid other eye medications unless your doctor approves.

AK-Spore (gramicidin, neomycin, and polymyxin B ophthalmic) side effects

Serious side effects are not expected with this medication.

Commonly, some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling or crusting, tearing, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect AK-Spore (gramicidin, neomycin, and polymyxin B ophthalmic)?

Avoid other eye medications unless they are approved by your doctor.

Drugs other than those listed here may also interact with gramicidin, neomycin, and polymyxin B ophthalmic. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More AK-Spore resources

• AK-Spore Side Effects (in more detail)
• AK-Spore Use in Pregnancy & Breastfeeding
• AK-Spore Support Group
• 0 Reviews for AK-Spore - Add your own review/rating

• Neocidin Prescribing Information (FDA)


• Neocidin Advanced Consumer (Micromedex) - Includes Dosage Information

Compare AK-Spore with other medications

• Conjunctivitis, Bacterial

Where can I get more information?

• Your pharmacist has additional information about gramicidin, neomycin, and polymyxin B written for health professionals that you may read.

See also: AK-Spore side effects (in more detail)

Mydral

Pronunciation: TROP-ik-ah-mide
Generic Name: Tropicamide
Brand Name: Examples include Mydral and Mydriacyl

Mydral is used for:

Dilating the pupil and paralyzing certain muscles in the eye for diagnostic tests. It may also be used for other conditions as determined by your doctor.

Mydral is an anticholinergic. It works by relaxing the muscles of the eye to cause the pupil to dilate or widen (mydriasis).

Do NOT use Mydral if:

• you are allergic to any ingredient in Mydral


• you have angle-closure glaucoma

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mydral:

Some medical conditions may interact with Mydral. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have glaucoma or you are at risk for glaucoma

Some MEDICINES MAY INTERACT with Mydral. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• Carbachol, ophthalmic cholinesterase inhibitors (eg, echothiophate), or pilocarpine because their effectiveness may be decreased by Mydral

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mydral may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mydral:

Use Mydral as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Remove contact lenses before using Mydral.


• First, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 2 or 3 minutes after using the medicine. Do not blink. Keep your eyes closed for 2 or 3 minutes. Remove excess medicine around your eye with a clean tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.


• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including your eye. Keep the container tightly closed.


• Use Mydral only in the eye. Do not get Mydral in your mouth or nose.


• Wash your hands after using Mydral. If the patient is a child, wash the child's hands as well.


• If you miss a dose of Mydral, contact your doctor for instructions.

Ask your health care provider any questions you may have about how to use Mydral.

Important safety information:

• Mydral may cause blurred vision or sensitivity to sunlight. Wear sunglasses if you are outside in the bright sunlight. Do not drive, operate machinery, or do anything else that could be dangerous unless you can see clearly.


• If you have an appointment for an eye examination and your doctor has told you that you will receive Mydral, be sure to make arrangements to have someone drive you home in case your vision is blurry.


• Mydral may be harmful if swallowed. If you may have taken Mydral by mouth, contact your local poison control center or emergency room immediately.


• Pupil dilation usually reverses within 4 to 8 hours after use, but may last as long as 24 hours.


• Caution is advised when using Mydral in CHILDREN because they may be more sensitive to its effects, especially mental or mood changes.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Mydral during pregnancy. It is unknown if Mydral is excreted in breast milk. If you are or will be breast-feeding while you are using Mydral, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Mydral:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; burning; dry mouth; headache; nausea; sensitivity to sunlight; temporary stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); behavioral changes, especially in children; eye pain; irregular or rapid heartbeat; mental or mood changes, especially in children; paleness or flushing of the skin; rigid muscles; shortness of breath; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Mydral side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Mydral:

Store Mydral at room temperature, between 46 and 80 degrees F (8 and 27 degrees C). Store away from heat, moisture, and light. Do not refrigerate. Do not store in the bathroom. Keep Mydral out of the reach of children and away from pets.

General information:

• If you have any questions about Mydral, please talk with your doctor, pharmacist, or other health care provider.


• Mydral is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Mydral. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Mydral resources

• Mydral Side Effects (in more detail)
• Mydral Use in Pregnancy & Breastfeeding
• Mydral Drug Interactions
• Mydral Support Group
• 0 Reviews for Mydral - Add your own review/rating

• Mydral Ophthalmic Advanced Consumer (Micromedex) - Includes Dosage Information


• Mydriacyl Prescribing Information (FDA)


• Mydriacyl Concise Consumer Information (Cerner Multum)


• Ocu-Tropic Advanced Consumer (Micromedex) - Includes Dosage Information


• Tropicacyl Prescribing Information (FDA)

Compare Mydral with other medications

• Pupillary Dilation
• Refraction, Assessment

Metformin

Pronunciation: met-FOR-min
Generic Name: Metformin
Brand Name: Glucophage

Metformin may rarely cause a serious and sometimes fatal condition called lactic acidosis. Most of these cases have occurred in diabetic patients who also have certain kidney problems. The risk of lactic acidosis may be greater if you have liver problems, kidney problems, or heart failure. The risk may also be greater in patients who are elderly or drink alcohol. Lab tests, including kidney function, may be performed while you take Metformin.

Do not begin to take Metformin if you are 80 years or older unless lab tests show that you do not have decreased kidney function. Do not take it if you have a severe infection, have low blood oxygen levels, or are dehydrated. Tell your doctor you take Metformin before you have any surgery or lab procedures.

Contact your doctor right away if you notice symptoms such as muscle pain or tenderness; unusual drowsiness, dizziness, or light-headedness; slow or irregular heartbeat; fast or difficult breathing; unusual stomach discomfort; or unusual weakness or tiredness. Contact your doctor right away if you start to feel unusually cold or if you have a general feeling of being unwell.

Metformin is used for:

Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Metformin is a biguanide antidiabetic. It works by decreasing the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

Do NOT use Metformin if:

• you are allergic to any ingredient in Metformin


• you have a severe infection, low blood oxygen levels, kidney or liver problems, high blood ketone or acid levels (eg, diabetic ketoacidosis), or dehydration


• you have had a stroke or a recent heart attack, or you are in shock


• you are 80 years or older and have not had a kidney function test


• you will be having surgery or certain lab procedures

Contact your doctor or health care provider right away if any of these apply to you.

Before using Metformin:

Some medical conditions may interact with Metformin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have heart failure, especially heart failure that is treated by medicine


• if you have a history of heart problems, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, or lactic acidosis


• if you have vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B₁₂ levels, or anemia, or if you are dehydrated


• if you have an infection, fever, recent injury, or moderate to severe burns


• if you drink alcohol or have a history of alcohol abuse


• if you will be having surgery or certain lab procedures


• if you take a beta-blocker (eg, propranolol)

Some MEDICINES MAY INTERACT with Metformin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin, or medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, tacrolimus) because they may increase the risk of Metformin's side effects. Ask you doctor if you are unsure if any of your medicines might harm the kidney


• Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, nicotinic acid, phenothiazine (eg, chlorpromazine), phenytoin, sulfonylureas (eg, glipizide), sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Metformin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Metformin:

Use Metformin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Metformin. Talk to your pharmacist if you have questions about this information.


• Take Metformin by mouth with food.


• Take Metformin on a regular schedule to get the most benefit from it. Taking Metformin at the same time each day will help you remember to take it.


• Continue to take Metformin even if you feel well. Do not miss any doses.


• If you miss a dose of Metformin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Metformin.

Important safety information:

• Metformin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Metformin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it


• Follow the diet and exercise program given to you by your health care provider.


• Do not drink large amounts of alcohol while you take Metformin. Talk to your doctor or health care provider before you drink alcohol while you take Metformin.


• Tell your doctor or dentist that you take Metformin before you receive any medical or dental care, emergency care, or surgery.


• Be careful not to become dehydrated, especially during hot weather or while you are being active. Dehydration may increase the risk of Metformin's side effects.


• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.


• Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Metformin exactly as prescribed, tell your doctor.


• Metformin does not usually cause low blood sugar. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. It may also be more likely if you take Metformin along with certain medicines for diabetes (eg, sulfonylureas, insulin). Tell your doctor right away if you experience symptoms of low blood sugar (eg, fast heartbeat, headache, chills, sweating, tremors, increased hunger, vision changes, nervousness, weakness, dizziness, drowsiness, fainting).


• It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.


• Fever, infection, injury, or surgery may increase your risk of high or low blood sugar levels. If any of these occur, check your blood sugar level closely and tell your doctor right away.


• Metformin may commonly cause stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis.


• Lab tests, including kidney function, fasting blood glucose, hemoglobin A_1c, and complete blood cell counts, may be performed while you take Metformin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Metformin with caution in the ELDERLY; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly.


• Metformin should not be used in CHILDREN younger than 10 years; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Metformin while you are pregnant. It is not known if Metformin is found in breast milk. Do not breast-feed while taking Metformin.

When used for long periods of time, Metformin may not work as well. If your blood sugar has been under control and then becomes hard to manage, contact your doctor. Do not change the dose of your medicine without checking with your doctor.

Possible side effects of Metformin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; headache; indigestion; nausea; stomach upset; temporary metallic taste; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; dizziness or light-headedness; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; muscle pain or weakness; slow or irregular heartbeat; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Metformin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness or light-headedness; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or tenderness; slow or irregular heartbeat; unusual drowsiness; unusual stomach discomfort; unusual weakness or tiredness.

Proper storage of Metformin:

Store Metformin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metformin out of the reach of children and away from pets.

General information:

• If you have any questions about Metformin, please talk with your doctor, pharmacist, or other health care provider.


• Metformin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Metformin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Metformin resources

• Metformin Side Effects (in more detail)
• Metformin Dosage
• Metformin Use in Pregnancy & Breastfeeding
• Drug Images
• Metformin Drug Interactions
• Metformin Support Group
• 90 Reviews for Metformin - Add your own review/rating

• Metformin Prescribing Information (FDA)


• Fortamet Prescribing Information (FDA)


• Glucophage Consumer Overview


• Glucophage Prescribing Information (FDA)


• Glucophage XR Prescribing Information (FDA)


• Glumetza Prescribing Information (FDA)


• Metformin Hydrochloride Monograph (AHFS DI)


• Riomet Consumer Overview


• Riomet Prescribing Information (FDA)


• metformin Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Metformin with other medications

• Diabetes, Type 2
• Female Infertility
• Insulin Resistance Syndrome
• Polycystic Ovary Syndrome

Umecta Topical Suspension

urea

Dosage Form: topical suspension
Umecta Topical Suspension

Description

Rx only

For topical use only

Not for ophthalmic use


Umecta is a keratolytic, emollient which is a gentle, yet potent, tissue softener for nails and skin



Each gram of Umecta® topical suspension contains 40% urea, butylated hydroxytoluene, butyrospermum parkii fruit oil, disodium EDTA, glyceryl stearate, glycine soja sterol, helianthus annuus oil, purified water, stearic

acid, sodium polyacrylate, and triethanolamine.

Clinical Pharmacology

Urea gently dissolves the intercellular matrix which results in loosening the horny layer of skin and shedding scaly skin at regular intervals, thereby softening hyperkeratotic areas. Urea also hydrates and gently dissolves the intercellular matrix of the nail plate which can result in the softening and eventual debridement of the nail plate.

Pharmacokinetics

The mechanism of action of topically applied urea is not yet known.

Indications and Uses

For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis, keratoderma, corns, and calluses, as well as damaged, ingrown and devitalized nails.

Contraindications

Known hypersensitivity to any of the listed ingredients.

Warnings

For external use only. Avoid contact with eyes, lips or mucous membranes.

Precautions

This medication is to be used as directed by a physician and should not be used to treat any condition other than that for which it was prescribed. If redness or irritation occurs, discontinue use.

Pregnancy Category C

Animal reproduction studies have not been conducted with Umecta. It is also not known whether Umecta can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Umecta should be given to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether or not this drug is secreted in human milk. Because many drugs are secreted in human milk, caution should be exercised when Umecta is administered to a nursing woman.

KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

Adverse Reactions

Transient stinging, burning, itching, or irritation may occur and normally disappear on discontinuing the medication.

Dosage and Administration

Apply Umecta Topical Suspension to affected skin twice per day or as directed by a physician. Rub in until completely absorbed.

How Supplied

Umecta® (urea, 40%) topical suspension supplied in a:


10 oz. bottle (topical suspension)

NDC 68712-005-01

Manufactured for:

Innocutis Holdings, LLC.

Charleston, SC 29401

Toll Free: 1-800-499-4468

www.innocutis.com

www.umecta.com

UMECTA   UREA urea   suspension

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 68712-005 Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength UREA (UREA) UREA 400 mg  in 1 g

Inactive Ingredients Ingredient Name Strength EDETATE DISODIUM   SHEA BUTTER   BUTYLATED HYDROXYTOLUENE   SOYBEAN OIL   SUNFLOWER OIL   GLYCERYL MONOSTEARATE   WATER   STEARIC ACID   TROLAMINE

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 68712-005-01 283.4 g In 1 TUBE None 2 68712-005-02 3 g In 1 PACKET None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved drug other		06/01/2004

Labeler - Innocutis Holdings, LLC (071501252)

Establishment
Name	Address	ID/FEI	Operations
Ei Inc.		105803274	manufacture

Revised: 11/2011Innocutis Holdings, LLC

More Umecta Topical Suspension resources

• Umecta Topical Suspension Side Effects (in more detail)
• Umecta Topical Suspension Use in Pregnancy & Breastfeeding
• Umecta Topical Suspension Support Group
• 0 Reviews for Umecta Topical - Add your own review/rating

Compare Umecta Topical Suspension with other medications

• Dermatological Disorders
• Dry Skin
• Pityriasis rubra pilaris

Jasochlor

Jasochlor may be available in the countries listed below.

Ingredient matches for Jasochlor

Chloroquine

Chloroquine phosphate (a derivative of Chloroquine) is reported as an ingredient of Jasochlor in the following countries:

• Bangladesh

International Drug Name Search

ecallantide

Generic Name: ecallantide (e KAL an tide)

Brand Names: Kalbitor

What is ecallantide?

Ecallantide is used to treat attacks of hereditary angioedema (an immune system disorder). This medication is used in people who are at least 16 years old.

Ecallantide is not a cure for hereditary angioedema.

Ecallantide may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about ecallantide?

You should not receive ecallantide if you are allergic to it.

Before you receive ecallantide, tell your doctor if you have a history of any type of allergy.

In an emergency situation it may not be possible before you are treated to tell your caregivers about your health conditions or if you are pregnant or breast-feeding. Make sure any doctor caring for you afterward knows that you have received this medication.

What should I discuss with my health care provider before receiving ecallantide?

You should not receive ecallantide if you are allergic to it.

Before you receive ecallantide, tell your doctor if you have a history of any type of allergy.

FDA pregnancy category C. It is not known whether ecallantide will harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether ecallantide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. In an emergency situation, it may not be possible before you are treated with ecallantide to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.

How is ecallantide given?

Ecallantide is injected under the skin. You will receive this injection in a clinic or hospital setting where you can be monitored in case the medication causes serious side effects.

Ecallantide is usually given in 3 separate injections. If you still have symptoms of the angioedema attack, more injections may be given within 24 hours.

What happens if I miss a dose?

Since ecallantide is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving ecallantide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Ecallantide side effects

Tell your caregivers right away if you have any of these signs of an allergic reaction within 1 hour after receiving ecallantide:

• 
  

  chest pain or discomfort, fast or weak heartbeat;

  
  


• 
  

  flushing (warmth, redness, or tingly feeling);

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  itching, rash, or hives;

  
  


• 
  

  runny nose, sneezing, stuffy nose;

  
  


• 
  

  wheezing, cough, throat irritation, trouble breathing; or

  
  


• 
  

  swelling of your face, lips, tongue, or throat.

  
  

An allergic reaction to ecallantide can cause symptoms that are very similar to the signs of hereditary angioedema. Your caregivers will watch you closely while you are receiving ecallantide to make sure you are not having an allergic reaction.

Less serious side effects may include:

• 
  

  headache;

  
  


• 
  

  stomach pain, nausea, vomiting, diarrhea;

  
  


• 
  

  fever;

  
  


• 
  

  tired feeling;

  
  


• 
  

  sore throat; or

  
  


• 
  

  pain, bruising, itching, redness, rash, or irritation where the injection was given.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ecallantide Dosing Information

Usual Adult Dose for Hereditary Angioedema:

30 mg subcutaneously in three 10 mg injections. If the attack persists, an additional dose of 30 mg may be administered within a 24 hour period.

Usual Pediatric Dose for Hereditary Angioedema:

16 years or older:
30 mg subcutaneously in three 10 mg injections. If the attack persists, an additional dose of 30 mg may be administered within a 24 hour period.

What other drugs will affect ecallantide?

There may be other drugs that can interact with ecallantide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More ecallantide resources

• Ecallantide Side Effects (in more detail)
• Ecallantide Use in Pregnancy & Breastfeeding
• Ecallantide Support Group
• 0 Reviews for Ecallantide - Add your own review/rating

• ecallantide Subcutaneous Advanced Consumer (Micromedex) - Includes Dosage Information


• Ecallantide Professional Patient Advice (Wolters Kluwer)


• Ecallantide MedFacts Consumer Leaflet (Wolters Kluwer)


• Ecallantide Monograph (AHFS DI)


• Kalbitor Prescribing Information (FDA)


• Kalbitor Consumer Overview

Compare ecallantide with other medications

• Hereditary Angioedema

Where can I get more information?

• Your doctor or pharmacist can provide more information about ecallantide.

See also: ecallantide side effects (in more detail)

Zamadol SR Capsules 50mg, 100mg, 150mg, 200mg

Please read this leaflet carefully before you start to take your medicine.

This leaflet provides a summary of the information known about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist.

Remember, this medicine is for you. Only a doctor can prescribe this medicine and it may harm someone else, even if their symptoms are the same as yours.

About your medicine

What is your medicine?

The name of your medicine is Zamadol SR Capsules (common name tramadol hydrochloride).

SR means that the capsules are sustained (slow) release.

There are four strengths of Zamadol SR Capsules:

Zamadol SR 50 mg Capsules contain 50 mg tramadol hydrochloride,

Zamadol SR 100 mg Capsules contain 100 mg tramadol hydrochloride,

Zamadol SR 150 mg Capsules contain 150 mg tramadol hydrochloride and

Zamadol SR 200 mg Capsules contain 200 mg tramadol hydrochloride.

Zamadol SR Capsules also contain sugar, maize starch, colloidal anhydrous silica, ethylcellulose, shellac and talc. The capsule coating contains gelatin and the approved colouring agents, titanium dioxide (E171) and/or iron oxide yellow (E172) and/or indigotin (E132). The printing ink contains shellac, propylene glycol and black iron oxide (E172).

The 50 mg SR Capsules are green, contain E171, E172 and E132, and are printed T50SR.

The 100 mg SR Capsules are white, contain E171, and are printed T100SR.

The 150 mg SR Capsules are dark green, contain E171, E172 and E132, and are printed T150SR.

The 200 mg SR Capsules are yellow, contain E171 and E172 and are printed T200SR.

All the capsules are packaged in blister strips of 10 capsules, with one, three or six blister strips in a carton.

What your medicine does

Zamadol SR Capsules are analgesics (pain killers or pain relievers). The active ingredient of Zamadol is tramadol; it interrupts the pain messages being sent to your brain, and it also acts in your brain to stop pain messages from being felt. This means that tramadol does not stop the pain from happening, but you will not be able to feel the pain as much.

Who produces your medicine?

The marketing authorisation for Zamadol SR Capsules is held by

MEDA Pharmaceuticals Ltd

Skyway House

Parsonage Road

Takeley

Bishop´s Stortford

CM22 6PU

Zamadol SR Capsules are manufactured by

Temmler Pharma GmbH & Co. KG

Temmlerstrasse 2

D-35039 Marburg

GERMANY

What your medicine is used for

Zamadol SR Capsules are used to relieve sudden or long-standing pain, either when the pain occurs or to prevent pain from occurring. The type of pain may be moderate or severe and it can be any type of pain, for example pain after an operation, or after an injury.

The sustained release capsules release the active ingredient over a period of time. Depending upon how much Zamadol you have taken and how bad your pain is, relief is normally felt within 30 minutes after taking Zamadol SR Capsules and lasts for about 12 hours. If you take Zamadol SR Capsules daily, your pain should be controlled.

Before taking your medicine

WARNING: Do not take Zamadol SR Capsules if:

• you are a child under 12 years old.



• you have ever had an allergic reaction to tramadol hydrochloride or any of the other ingredients in this medicine.



• you are taking, or have you taken in the last two weeks, monoamine oxidase inhibitors (MAOIs) – these are medicines to treat depression.



• you are suffering from uncontrolled epilepsy.



• you have taken enough alcohol to make you feel even slightly drunk or you have taken several sleeping pills, other pain killers or any other medicines which slow down your thinking or breathing rate.



• you are pregnant or breast-feeding.

If the answer to any of the following questions is “yes”, you must tell your doctor – he may decide to alter your treatment:

• Have you been taking Zamadol or any other tramadol containing medicine for a long time?



• Are you addicted to morphine?



• Have you had an allergic reaction to any morphine-like medicines?



• Do you have severe problems with your liver or kidneys?



• Have you recently had a head injury or do you have a very bad headache that makes you sick?



• Have you ever had convulsions (fits) or do you suffer from epilepsy?



• Do you have asthma or trouble breathing?



• Are you taking any tranquillisers or antidepressants or treatment for epilepsy?

What about other medicines that you may be taking?

Some medicines used to treat epilepsy, some antidepressants and tranquillisers may cause convulsions (fits). This is rare, but if you are also taking Zamadol SR Capsules the possibility of having a convulsion (fit) is more likely.You must ask your doctor about this.

If you are taking carbamazepine for epilepsy, anticoagulants such as warfarin or monoamine oxidase inhibitors for depression, you must also tell your doctor.

Zamadol SR Capsules may cause drowsiness and this effect may be increased by antidepressant medication, or other medicines which slow down your nervous system (making you feel faint). These include sleeping pills, tranquillisers, other pain killers (such as buprenorphine, nalbuphine and pentazocine) or a general anaesthetic. Tell your doctor or dentist if you are taking any of these medicines.

What about food and drink?

Zamadol SR Capsules are not known to react badly with food or soft drinks. It is better not to drink alcohol with this medicine.

Special warnings

This medicine contains sucrose.

Driving and using machines

Zamadol SR Capsules may make you feel drowsy. Do not drive or operate heavy machinery unless you know how Zamadol SR Capsules affect you.

Taking your medicine

How to take your medicine

Follow your doctor's instructions on how many Zamadol SR Capsules you should take and when to take them.You should normally take your Zamadol SR Capsules every 12 hours, for example first thing in the morning and then at the same time in the evening. The number of capsules you take will depend upon the dose your doctor prescribes, but you should not take them more frequently than every 12 hours. Normally you should not take more than 400 mg tramadol per day. If you are not sure how many capsules to take or when to take them, ask your doctor or pharmacist.

Swallow the capsules whole with water without chewing.

If you have difficulty in swallowing, your doctor may advise you to open the capsules. The capsules should be opened very carefully by pulling and twisting each end. The capsule should be opened over a spoon so that all the pellets stay in the spoon. The pellets should then be swallowed, take a sip of water afterwards to make sure that you have swallowed all the pellets. Remember that the pellets should not be chewed.

What to do if you forget to take your medicine

If you forget to take your medicine, take it as soon as you remember then take the next dose 12 hours later, but DO NOT TAKE MORE THAN ONE DOSE AT THE SAME TIME.

What to do if you see a different doctor, or have to go to hospital

If you see another doctor or have to go to hospital for any reason, tell them about all the medicines you are taking including Zamadol.

What to do if you take an overdose

If you ever take too many capsules or if a child accidentally takes Zamadol SR Capsules contact your nearest hospital casualty department or tell your doctor immediately.

After taking your medicine

Zamadol SR Capsules, like all other medicines, may have side-effects.You may not have any of these side-effects or you may have some of them.

These side-effects may include feeling sick or being sick, sweating, a dry mouth, drowsiness, tiredness, dizziness (especially after standing up suddenly from a sitting down position), headache, constipation or shortness of breath.

Zamadol SR Capsules may (rarely) also cause dependence (addiction), blurred vision, tingling sensations, hallucinations, nightmares and sleep disturbances, confusion, changes in mood such as feelings of sadness, nervousness or fidgetiness, fits (convulsions), tremor, rapid or slow heart beat, an increase or fall in blood pressure, flushing or blood changes, difficulty passing urine, minor changes in liver function, irritation of the stomach (feeling of bloatedness) and changes in appetite. In very rare cases withdrawal symptoms may be experienced when your treatment is stopped.

An allergic reaction to tramadol could make your asthma worse if you already have asthma, or it could make you feel as though breathing is difficult. Allergic reactions to tramadol may also include itching or skin rash. In very rare cases a very severe allergic reaction called anaphylaxis may occur. If you experience any of these allergic reactions, please stop taking the capsules and contact your doctor immediately.

If you have any questions about these side-effects, or if you notice any other side-effects or problems, you should tell your doctor or pharmacist.

How to store your medicine

• Keep your capsules in the original package and in a safe place where children cannot see or reach them.Your capsules could harm them.



• Do not use your capsules after the expiry date on the box, even if there are some capsules left. Ask your doctor to replace them with a new prescription and take any unused capsules back to the pharmacist.



• If your doctor tells you to stop taking the capsules, please take them back to the pharmacist.

This leaflet was written in June 1998 and revised in June 2008.

ZAMADOL is a registered trademark of MEDA

© MEDA

70037142-2308/46

chlorpheniramine, methscopolamine, and pseudoephedrine

Generic Name: chlorpheniramine, methscopolamine, and pseudoephedrine (KLOR fen IR a meen, METH skoe POL a meen, SOO doe ee FED rin)

Brand names: AllePak, Allergy AM-PM Dose Pack, Allergy DN, Amdry-C, Durahist, Hista-Vent PSE, PCM-LA, Pseudo CM TR, Rhinaclear, Time-Hist QD, VisRx Dose Pack, ...show all 20 brand names.Mescolor, Rescon MX (obsolete), AlleRx Dose Pack (obsolete), Histatab, Dallergy PSE, Coldamine, RelCof DN PSE, ScopoHist, DryMax

What is chlorpheniramine, methscopolamine, and pseudoephedrine?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Methscopolamine reduces the secretions of certain organs in the body.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, methscopolamine, and pseudoephedrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

Chlorpheniramine, methscopolamine, and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about chlorpheniramine, methscopolamine, and pseudoephedrine?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use a cough or cold if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Do not use this medication if you are allergic to chlorpheniramine or methscopolamine, or if you have severe high blood pressure or coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or if you are unable to urinate.

Do not use this medication during an asthma attack.

Avoid drinking alcohol while you are taking this medication.

What should I discuss with my healthcare provider before taking chlorpheniramine, methscopolamine, and pseudoephedrine?

Do not use a cough or cold if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Dangerous side effects may occur if you take a cough or cold medicine before the MAO inhibitor has cleared from your body. Do not use this medication if you are allergic to chlorpheniramine, methscopolamine, or pseudoephedrine, or if you have:

• 
  

  severe or uncontrolled high blood pressure;

  
  


• 
  

  severe coronary artery disease;

  
  


• 
  

  narrow angle glaucoma;

  
  


• 
  

  a stomach ulcer;

  
  


• 
  

  if you are unable to urinate; or

  
  


• 
  

  if you are having an asthma attack.

  
  

Before using chlorpheniramine, methscopolamine, and pseudoephedrine, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;


• liver disease;


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  heart disease, high blood pressure, or circulation problems;

  
  


• 
  

  overactive thyroid;

  
  


• 
  

  a seizure disorder such as epilepsy;

  
  


• 
  

  asthma, emphysema or chronic bronchitis; or

  
  


• 
  

  urination problems or an enlarged prostate.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Chlorpheniramine, methscopolamine, and pseudoephedrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take chlorpheniramine, methscopolamine, and pseudoephedrine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the instructions on your prescription label. Cold medicine is usually taken for only a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take this medicine with a full glass of water. Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

Contact your doctor if your symptoms do not improve or if they get worse while using this medication.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are taking an antihistamine.

Store chlorpheniramine, methscopolamine, and pseudoephedrine at room temperature away from moisture, heat, and light.

See also: Chlorpheniramine, methscopolamine, and pseudoephedrine dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, severe drowsiness, shallow breathing, ringing in your ears, problems with balance or coordination, hallucinations (seeing things), sleep problems (insomnia), feeling restless or excited, blurred vision, tremors, flushed face, and seizure (convulsions).

What should I avoid while taking chlorpheniramine, methscopolamine, and pseudoephedrine?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated in hot weather. Chlorpheniramine, methscopolamine, and pseudoephedrine increases the risk of heat stroke because it causes decreased sweating and can make you more sensitive to sunlight.

Avoid drinking alcohol. It can increase some of the side effects of chlorpheniramine, methscopolamine, and pseudoephedrine. Narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by chlorpheniramine or methscopolamine. Tell your doctor if you regularly use any of these medicines, or any other cold or allergy medications.

Chlorpheniramine, methscopolamine, and pseudoephedrine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  numbness, tingling, or cold feeling in your hands or feet;

  
  


• 
  

  fast, pounding, or uneven heart beats;

  
  


• 
  

  painful or difficult urination;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  feeling short of breath;

  
  


• 
  

  tremors or shaking; or

  
  


• 
  

  severe drowsiness, feeling light-headed, fainting.

  
  

Less serious side effects may include:

• 
  

  dry mouth, stomach pain, changes in appetite;

  
  


• 
  

  drowsiness, dizziness, weakness, headache;

  
  


• 
  

  dry eyes, blurred vision;

  
  


• 
  

  increased sweating;

  
  


• 
  

  skin rash; or

  
  


• 
  

  feeling nervous or excited (especially in children).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Chlorpheniramine, methscopolamine, and pseudoephedrine Dosing Information

Usual Adult Dose for Allergic Rhinitis:

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-30 mg/ 5 mL oral syrup:
5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-60 mg oral tablet, extended release:
1 to 2 tablets orally every 12 hours not to exceed 2 doses daily.

Chlorpheniramine/methscopolamine/PSE 6 mg-2.5 mg-120 mg oral tablet, extended release:
1 tablet orally per day.

Usual Adult Dose for Nasal Congestion:

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-30 mg/ 5 mL oral syrup:
5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-60 mg oral tablet, extended release:
1 to 2 tablets orally every 12 hours not to exceed 2 doses daily.

Chlorpheniramine/methscopolamine/PSE 6 mg-2.5 mg-120 mg oral tablet, extended release:
1 tablet orally per day.

Usual Adult Dose for Sinus Symptoms:

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-30 mg/ 5 mL oral syrup:
5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-60 mg oral tablet, extended release:
1 to 2 tablets orally every 12 hours not to exceed 2 doses daily.

Chlorpheniramine/methscopolamine/PSE 6 mg-2.5 mg-120 mg oral tablet, extended release:
1 tablet orally per day.

Usual Pediatric Dose for Allergic Rhinitis:

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-30 mg/ 5 mL oral syrup:
6 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 20 mL daily.
12 years or older: 5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-60 mg oral tablet, extended release:
6 to 11 years: 1 tablet orally every 12 hours not to exceed 2 doses daily.
12 years or older: 1 to 2 tablets orally every 12 hours not to exceed 2 doses daily.

Chlorpheniramine/methscopolamine/PSE 6 mg-2.5 mg-120 mg oral tablet, extended release:
12 years or older: 1 tablet orally per day.

Usual Pediatric Dose for Nasal Congestion:

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-30 mg/ 5 mL oral syrup:
6 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 20 mL daily.
12 years or older: 5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-60 mg oral tablet, extended release:
6 to 11 years: 1 tablet orally every 12 hours not to exceed 2 doses daily.
12 years or older: 1 to 2 tablets orally every 12 hours not to exceed 2 doses daily.

Chlorpheniramine/methscopolamine/PSE 6 mg-2.5 mg-120 mg oral tablet, extended release:
12 years or older: 1 tablet orally per day.

Usual Pediatric Dose for Sinus Symptoms:

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-30 mg/ 5 mL oral syrup:
6 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 20 mL daily.
12 years or older: 5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Chlorpheniramine/methscopolamine/PSE 4 mg-1.25 mg-60 mg oral tablet, extended release:
6 to 11 years: 1 tablet orally every 12 hours not to exceed 2 doses daily.
12 years or older: 1 to 2 tablets orally every 12 hours not to exceed 2 doses daily.

Chlorpheniramine/methscopolamine/PSE 6 mg-2.5 mg-120 mg oral tablet, extended release:
12 years or older: 1 tablet orally per day.

What other drugs will affect chlorpheniramine, methscopolamine, and pseudoephedrine?

Many drugs can interact with chlorpheniramine, methscopolamine, and pseudoephedrine. Below is just a partial list. Tell your doctor if you are using any of these drugs:

• 
  

  antacids;

  
  


• 
  

  medicine to treat diarrhea (such as Immodium, Kaopectate, Pepto-Bismol);

  
  


• 
  

  atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

  
  


• 
  

  bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);

  
  


• 
  

  glycopyrrolate (Robinul);

  
  


• 
  

  mepenzolate (Cantil);

  
  


• 
  

  bladder or urinary medications such as darifenacin (Enablex), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

  
  


• 
  

  irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine);

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta, Ziac), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), timolol (Blocadren), and others;

  
  


• 
  

  a barbiturate such as phenobarbital (Luminal, Solfoton); or

  
  


• 
  

  an antidepressant such as amitriptyline (Elavil, Etrafon), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Janimine, Tofranil), and others.

  
  

This list is not complete and there may be other drugs that can interact with chlorpheniramine, methscopolamine, and pseudoephedrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More chlorpheniramine, methscopolamine, and pseudoephedrine resources

• Chlorpheniramine, methscopolamine, and pseudoephedrine Dosage
• Chlorpheniramine, methscopolamine, and pseudoephedrine Use in Pregnancy & Breastfeeding
• Chlorpheniramine, methscopolamine, and pseudoephedrine Drug Interactions
• Chlorpheniramine, methscopolamine, and pseudoephedrine Support Group
• 4 Reviews for Chlorpheniramine, methscopolamine, and pseudoephedrine - Add your own review/rating

Compare chlorpheniramine, methscopolamine, and pseudoephedrine with other medications

• Hay Fever
• Nasal Congestion
• Sinus Symptoms

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine, methscopolamine, and pseudoephedrine written for health professionals that you may read.

Short Bowel Syndrome Medications

Definition of Short Bowel Syndrome: A condition of malabsorption related to the surgical removal or disease of a large portion of the small intestine.

Drugs associated with Short Bowel Syndrome

The following drugs and medications are in some way related to, or used in the treatment of Short Bowel Syndrome. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Short Bowel Syndrome

Medical Encyclopedia:

• Short bowel syndrome

Drug List:

Accretropin

Glutasolve

Norditropin-Flexpro

Norditropin-Nordiflex

Nutrestore

Sympt-X-G-I

Zorbtive

Visudyne

Pronunciation: ver-teh-POR-fin
Generic Name: Verteporfin
Brand Name: Visudyne

Visudyne is used for:

Treating macular degeneration, pathologic myopia, and presumed histoplasmosis infection of the eye. It may also be used for other conditions as determined by your doctor.

It works by causing clotting in the blood vessels of the eye, which decreases damage already done in the eye.

Do NOT use Visudyne if:

• you are allergic to any ingredient in Visudyne


• you have the blood disease porphyria

Contact your doctor or health care provider right away if any of these apply to you.

Before using Visudyne:

Some medical conditions may interact with Visudyne. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have liver problems or a blockage of your bile duct


• if you are undergoing radiation therapy

Some MEDICINES MAY INTERACT with Visudyne. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Calcium channel blockers (eg, verapamil), griseofulvin, phenothiazines (eg, chlorpromazine), sulfonamides (eg, sulfamethoxazole), sulfonylureas (eg, glipizide), tetracyclines (eg, doxycycline), or thiazide diuretics (eg, hydrochlorothiazide) because the side effects of Visudyne may be increased


• Anticoagulants (eg, warfarin), aspirin, beta-carotene (eg, vitamin A), dimethyl sulfoxide, formate, or mannitol because the effectiveness of Visudyne may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Visudyne may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Visudyne:

Use Visudyne as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Visudyne is usually administered as an injection at your doctor's office, hospital, or clinic.


• If you miss a dose of Visudyne, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Visudyne.

Important safety information:

• Visudyne may cause blurred vision or other vision changes. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Visudyne. Using Visudyne alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Visudyne causes sensitivity to bright light for 5 days following treatment. Avoid exposure to sunlight, sunlamps, tanning booths, bright halogen lighting, and all other bright, indoor light for 5 days following treatment with Visudyne. Use of a sunscreen is not effective protection. Wear protective clothing over all skin and dark sunglasses if you must be outside, even for a short period of time.


• Avoid getting Visudyne on the skin or in the eyes.


• Avoid surgery or dental procedures during the 5 days following infusion of Visudyne.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Visudyne.


• Use Visudyne with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Visudyne, discuss with your doctor the benefits and risks of using Visudyne during pregnancy. It is unknown if Visudyne is excreted in breast milk. If you are or will be breast-feeding while you are using Visudyne, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Visudyne:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision or other vision changes; headache; mild discomfort or redness at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); pain or swelling at the injection site; sensitivity to bright light lasting more than 5 days after your dose; severe vision changes or vision loss; skin rash or severe sunburn.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Visudyne side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Visudyne:

Visudyne is usually handled and stored by a health care provider. If you are using Visudyne at home, store Visudyne as directed by your pharmacist or health care provider. Keep Visudyne out of the reach of children and away from pets.

General information:

• If you have any questions about Visudyne, please talk with your doctor, pharmacist, or other health care provider.


• Visudyne is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Visudyne. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Visudyne resources

• Visudyne Side Effects (in more detail)
• Visudyne Use in Pregnancy & Breastfeeding
• Visudyne Drug Interactions
• Visudyne Support Group
• 0 Reviews for Visudyne - Add your own review/rating

• Visudyne Prescribing Information (FDA)


• Visudyne Concise Consumer Information (Cerner Multum)


• Visudyne Monograph (AHFS DI)


• Visudyne Advanced Consumer (Micromedex) - Includes Dosage Information

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Meloxicam Suspension

Pronunciation: mel-OX-i-kam
Generic Name: Meloxicam
Brand Name: Mobic

Meloxicam Suspension is a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you take Meloxicam Suspension for a long time. Do not use Meloxicam Suspension right before or after bypass heart surgery.

Meloxicam Suspension may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.

Meloxicam Suspension is used for:

Treating rheumatoid arthritis, osteoarthritis, and juvenile arthritis. It may also be used for other conditions as determined by your doctor.

Meloxicam Suspension is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use Meloxicam Suspension if:

• you are allergic to any ingredient in Meloxicam Suspension


• you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, celecoxib)


• you have recently had or will be having bypass heart surgery


• you have a peptic ulcer


• you are in the last 3 months of pregnancy


• you take sodium polystyrene sulfonate

Contact your doctor or health care provider right away if any of these apply to you.

Before using Meloxicam Suspension:

Some medical conditions may interact with Meloxicam Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of kidney or liver disease, diabetes, stomach or bowel problems (eg, bleeding, perforation, ulcers), or H. pylori infection


• if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation


• if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases


• if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol or smoke, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Meloxicam Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), antiplatelet medicines (eg, clopidogrel), aspirin, bisphosphonates (eg, alendronate), corticosteroids (eg, prednisone), dabigatran, desirudin, heparin, rivaroxaban, or serotonin reuptake inhibitors (eg, fluoxetine) because the risk of stomach bleeding may be increased


• Sodium polystyrene sulfonate because a serious and possibly fatal bowel problem (intestinal necrosis) may occur


• Probenecid because it may increase the risk of Meloxicam Suspension's side effects


• Cholestyramine because it may decrease Meloxicam Suspension's effectiveness


• Cyclosporine, lithium, methotrexate, quinolones (eg, ciprofloxacin), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Meloxicam Suspension


• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin receptor blockers (eg, losartan), or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Meloxicam Suspension and the risk of kidney problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Meloxicam Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Meloxicam Suspension:

Use Meloxicam Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Meloxicam Suspension comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Meloxicam Suspension refilled.


• Take Meloxicam Suspension by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers).


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Shake gently before each use.


• Take Meloxicam Suspension with a full glass of water (8 oz/240 mL) as directed by your doctor.


• If you miss a dose of Meloxicam Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Meloxicam Suspension.

Important safety information:

• Meloxicam Suspension may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Meloxicam Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Serious stomach ulcers or bleeding can occur with the use of Meloxicam Suspension. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Meloxicam Suspension with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Meloxicam Suspension has an NSAID in it. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Do not take aspirin while you are using Meloxicam Suspension unless your doctor tells you to.


• Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be performed while you use Meloxicam Suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Meloxicam Suspension with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.


• Caution is advised when using Meloxicam Suspension in CHILDREN; they may be more sensitive to its effects, especially diarrhea, fever, headache, stomach pain, and vomiting.


• Meloxicam Suspension should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been determined.


• PREGNANCY and BREAST-FEEDING: Meloxicam Suspension may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Meloxicam Suspension while you are pregnant. It is not known if Meloxicam Suspension is found in breast milk. Do not breast-feed while taking Meloxicam Suspension.

Possible side effects of Meloxicam Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; mild stomach pain; nausea; stomach upset; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; difficult or painful urination; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; loss of appetite; mental or mood changes (eg, depression); numbness of an arm or leg; one-sided weakness; pale stools; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe or persistent headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Meloxicam side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; decreased urination; loss of consciousness; seizures; severe dizziness, headache, or drowsiness; severe nausea, vomiting, or stomach pain; slow or troubled breathing; sluggishness; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, severe stomach pain, yellowing of the skin or eyes); symptoms of stomach or bowel bleeding (eg, bloody or black, tarry stools; vomit that looks like coffee grounds).

Proper storage of Meloxicam Suspension:

Store Meloxicam Suspension at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Meloxicam Suspension out of the reach of children and away from pets.

General information:

• If you have any questions about Meloxicam Suspension, please talk with your doctor, pharmacist, or other health care provider.


• Meloxicam Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Meloxicam Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Meloxicam resources

• Meloxicam Side Effects (in more detail)
• Meloxicam Use in Pregnancy & Breastfeeding
• Drug Images
• Meloxicam Drug Interactions
• Meloxicam Support Group
• 109 Reviews for Meloxicam - Add your own review/rating

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